This interdisciplinary project is designed to consider the development of appropriate systems to manufacture liposome-based drug delivery and will be based within two of our research groups: (Prof Perrie and Dr Rattray). The research is focused on developing new formulations and new processes for the production of liposomes for the delivery of anti-cancer agents. The project will investigate a range of small molecules for the treatment of cancer and will investigate their formulation into a range of liposome systems. Nanotechnology will be exploited to improve cellular targeting allowing for improved drug efficacy and reduced side effect profiles. The biological actions and interactions will also be investigated. A range of pharmaceutical analysis tools will be used to investigate and characterise the new compounds and a suite of manufacturing facilities will be used to formulate, characterise and optimise the formulations to improve drug targeting.

Techniques used

This project will involve a range of liposomal formulations. These systems will be formulated and optimised for their drug loading potential and then surface functionalised to exploit effective targeting strategies.