Dr Nicholas Rattray

Senior Lecturer

Strathclyde Institute of Pharmacy and Biomedical Sciences

Personal statement

Principle research interests lie in investigating metabolic changes throughout human life course with a focus on the dynamics of energy metabolism alongside biomarker detection. Currently developing a targeted research theme that incorporates pregnancy, frailty and ageing related clinical projects alongside novel analytical approaches that enable the targeting and quantification of pathways critical to biochemical energy production. Portfolio of clinical research has covered a broad range of concepts including: Population level analysis of frailty metabolism Early diagnostic and theranostic biomarker detection Energy metabolism across the placenta Ageing effects the biological and metabolic basis of cancer This work has also been complemented by development of statistical tools to understand how metabolite data can be automatically linked to biochemical pathways, helping to inform genomic studies and ultimately to develop models linking metabolic data and exposures to epidemiological studies. Expertise & Capabilities Lab has broad experience in: Development of cellular models of disease and ageing Technical application of untargeted and targeted mass spectrometry based metabolomics pipelines with a view to high through-put levels of analysis Automation of pre/post processing and informatics Development of imaging mass spectrometry capability Enabling of a broad range of targeted MS workflow focusing on energy metabolites

Expertise

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Area of Expertise

Lab has broad experience in

Development of cellular models of disease and ageing
Technical application of untargeted and targeted mass spectrometry based metabolomics pipelines with a view to high through-put levels of analysis
Automation of pre/post processing and informatics
Development of imaging mass spectrometry capability.
Enabling of a broad range of targeted MS workflow focusing on energy metabolites

Publications

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Publications

Changes in frailty status and discharge destination post emergency laparotomy: Ng Hwei Jene, Rattray Nicholas J W, Quasim Tara, Moug Susan J; World Journal of Emergency Surgery Vol 20 (2025); https://doi.org/10.1186/s13017-025-00612-8
Biomarkers of dietary intake in faeces of children with Crohn’s disease and their role in disease recurrence following treatment with exclusive enteral nutrition: Gerasimidis K, Gkikas K, Rentaki P, Morrison D, Russell R, Rattray N, Havlik J; Journal of Crohn's and Colitis Vol 19, pp. i2533-i2533 (2025); https://doi.org/10.1093/ecco-jcc/jjae190.1600
Spatial lipidomic profiles of atherosclerotic plaques : a mass spectrometry imaging study: Ntshangase Sphamandla, Khan Shazia, Bezuidenhout Louise, Gazárková Taťána, Kaczynski Jakub, Sellers Stephanie, Rattray Nicholas Jw, Newby David E, Hadoke Patrick Wf, Andrew Ruth; Talanta Vol 282 (2025); https://doi.org/10.1016/j.talanta.2024.126954
Recounting the untold stories of breast cancer patient experiences : lessons learned from a patient-public involvement and engagement (PPIE) storytelling event: Cunningham Margaret R, Rattray Nicholas JW, McFadden Yvonne, Berardi Domenica, Daramy Karim, Kelly Patricia E, Galbraith Allison, Lochiel Isobel, Mills Lorraine, Scott Yvonne, Chalmers Susan, Lannigan Alison, Rattray Zahra; International Journal of Pharmacy Practice Vol 32, pp. 515-523 (2024); https://doi.org/10.1093/ijpp/riae052
An expert consensus statement on biomarkers of ageing for use in intervention studies: Perri Giorgia, French Chloe, Agostinis-Sobrinho César, Anand Atul, Antarianto Radiana Dhewayani, Arai Yasumichi, Baur Joseph A, Cauli Omar, Clivaz-Duc Morgane, Colloca Giuseppe, Demetriades Constantinos, de Lucia Chiara, Di Gessa Giorgio, Diniz Breno S, Dotchin Catherine L, Eaglestone Gillian, Elliott Bradley T, Espeland Mark A, Ferrucci Luigi, Fisher James, Grammatopoulos Dimitris K, Hardiany Novi S, Hassan-Smith Zaki, Hastings Waylon J, Jain Swati, Joshi Peter K, Katsila Theodora, Kemp Graham J, Khaiyat Omid A, Lamming Dudley W, Gallegos Jose Lara, Madeo Frank, Maier Andrea B, Martin-Ruiz Carmen, Martins Ian J, Mathers John C, Mattin Lewis R, Merchant Reshma A, Moskalev Alexey, Neytchev Ognian, Ni Lochlainn Mary, Owen Claire M, Phillips Stuart M, Pratt Jedd, Prokopidis Konstantinos, Rattray Nicholas J W, Rúa-Alonso María, Schomburg Lutz, Scott David, Shyam Sangeetha, Sillanpää Elina, Tan Michelle M C, Teh Ruth, Tobin Stephanie W, Vila-Chã Carolina J, Vorluni Luigi, Weber Daniela, Welch Ailsa, Wilson Daisy, Wilson Thomas, Zhao Tongbiao, Philippou Elena, Korolchuk Viktor I, Shannon Oliver M; The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences Vol 80 (2024); https://doi.org/10.1093/gerona/glae297
Beneficial modulation of the gut microbiome by leachates of Penicillium purpurogenum in the presence of clays : a model for the preparation and efficacy of historical Lemnian Earth: Milling Simon, Ijaz Umer Zeeshan, Venieri Danae, Christidis Georgios E, Rattray Nicholas J W, Gounaki Iosifina, Andrusaite Anna, Knapp Charles W, Jones Alexander X, Photos-Jones Effie; PLoS ONE Vol 19 (2024); https://doi.org/10.1371/journal.pone.0313090

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Research

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Professional Activities

Data & AI Meetup: Life Sciences: Speaker; 2/4/2025
Podcast on Mentorship Across Borders: Speaker; 10/12/2024
Defining Biomarkers of Surgical Frailty (ACORN WELCOME LEAP): Speaker; 2/12/2024
Invited Speaker at the UK Mass Spec Tech Forum: Speaker; 30/11/2024
Defining Biomarkers of Surgical Frailty (REBOUND WELCOME LEAP): Speaker; 25/11/2024
PhD Examination - University of Manchester (Holly Leather): Examiner; 22/11/2024

More professional activities

Projects

DTP 2224 University of Strathclyde | Almawazini, Mohammad: Rattray, Nicholas (Principal Investigator) Rattray, Zahra (Co-investigator) Almawazini, Mohammad (Research Co-investigator); 01-Jan-2025 - 01-Jan-2028
Frailty (eFI JARSS NHS Monies): Rattray, Nicholas (Principal Investigator); 01-Jan-2024 - 31-Jan-2028
Dxcover Brain Cancer Analysis: Rattray, Nicholas (Principal Investigator) Rattray, Zahra (Co-investigator); 01-Jan-2024 - 30-Jan-2025
Dementia biomarker detection using resonant Raman spectroscopy at point of need.: Rattray, Nicholas (Principal Investigator); 01-Jan-2024 - 31-Jan-2025
iCAL Strathclyde CDT - Industry Contribution: Rattray, Nicholas (Principal Investigator); 01-Jan-2023 - 30-Jan-2026
Harnessing multiparametric biobank data to develop novel predictive models of frailty: Rattray, Nicholas (Principal Investigator); 30-Jan-2023 - 26-Jan-2025