Professor Paul Hoskisson

Strathclyde Institute of Pharmacy and Biomedical Sciences

Contact

Personal statement

Laboratory webpage is here http://paulhoskisson.weebly.com

Research in my group is focussed on the evolution and synthesis of natural products (partricularly antibiotics) and the evolution of the organisms that produce them, using a range of techniques from molecular biology and biochemistry through to mathematical modelling and experimental evolution.

The bacterial genus Streptomyces is the main focus of work in my Research Group due to its industrial importance, being responsible for producing around two thirds of all commercially important antibiotics as well as numerous anti-fungal, anti-helminthic and anti-cancer drugs. 

We also have an interest in evolution of metabolism, evolution of bacterial pathogens, genomics of actinobacteria and the exploitation of amphibian proteins for biotechnology. 

I am currently the Royal Academy of Engineering Research Chair in Engineering Biology at University of Strathclyde. I was elected as a Fellow of the Royal Society of Edinburgh (2021) and a Fellow of the Royal Society of Biology (FRSB) in 2016.

I am a member of the Microbiology Society, the American Society of Microbiology, The society for Molecular Biology and Evolution, the Biochemical Society, The Royal Society of Biology and British Herpetological Society.

I am a senior editor for Microbial Genomics.

I am a Fellow of the Higher Education Academy.

I am interested in the use of Social media for communication of science and you can follow on Bluesky @paulhoskisson.bsky.social

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Publications

Evaluating the protective effects of Aurodox in a murine model of Shiga toxin-producing Escherichia coli
McHugh Rebecca E, Rooney Liam M, Mark David R, Wale Kabo R, Clapperton Megan, McConnell Gail, Hoskisson Paul A, Douce Gillian R, Roe Andrew J
Antimicrobials and Resistance Vol 3 (2025)
https://doi.org/10.1038/s44259-025-00094-3
Oxygen microenvironments in E. coli biofilm nutrient transport channels : insights from complementary sensing approaches
Bottura Beatrice, McConnell Gail, Florek Lindsey, Smiley Marina, Martin Ross, Eana Ash, Dayton Hannah, Eckartt Kelly, Price-Whelan Alexa, Hoskisson Paul, Dietrich Lars, Rooney Liam
Microbiology (2025)
https://doi.org/10.1099/mic.0.001543
Whole-genome sequencing of the Streptomyces coelicolor bldA39 mutant (J1700) reveals hundreds of previously unknown mutations
Stone Jack W, Munnoch John T, Hoskisson Paul A
Access Microbiology Vol 7 (2025)
https://doi.org/10.1099/acmi.0.000958.v3
Biocatalytic synthesis of ribonucleoside analogues using nucleoside transglycosylase-2
Salihovic Admir, Ascham Alex, Rosenqvist Petja S, Taladriz-Sender Andrea, Hoskisson Paul A, Hodgson David R W, Grogan Gideon, Burley Glenn A
Chemical Science Vol 16, pp. 1302-1307 (2024)
https://doi.org/10.1039/D4SC07521H
Quantifying the fractal complexity of nutrient transport channels in Escherichia coli biofilms under varying cell shape and growth environment
Bottura Beatrice, Rooney Liam, Feeney Morgan, Hoskisson Paul A, McConnell Gail
Microbiology Vol 170 (2024)
https://doi.org/10.1099/mic.0.001511
Gram-scale enzymatic synthesis of 2′-deoxyribonucleoside analogues using nucleoside transglycosylase-2
Salihovic Admir, Ascham Alex, Taladriz-Sender Andrea, Bryson Samantha, Withers Jamie M, Mckean Iain J W, Hoskisson Paul A, Grogan Gideon, Burley Glenn A
Chemical Science Vol 15, pp. 15399-15407 (2024)
https://doi.org/10.1039/D4SC04938A

More publications

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Professional Activities

BBSRC (Biotech & Biological Sciences Research Council) (External organisation)
Advisor
23/9/2024
BBSRC (Biotech & Biological Sciences Research Council) (External organisation)
Advisor
21/2/2024
Joint Programme Initiative on Antimicrobial Resistance (External organisation)
Advisor
1/1/2024
The drugs don't work: Understanding antimicrobial resistance
Speaker
28/10/2023
Investigating the fractal nature of channels within E. coli biofilms with altered cell phenotype
Contributor
25/7/2023
Investigating the influence of cell shape on intra-colony channel architecture by fractal analysis of confocal microscopy biofilm images
Contributor
4/7/2023

More professional activities

Projects

Co-evolution of Streptomyces spp. with Candida auris to express cryptic novel antifungals.
Larcombe, Daniel (Principal Investigator) Hoskisson, Paul (Co-investigator)
01-Jan-2025 - 31-Jan-2027
Disarming Type 3 Secretion - elucidating the mechanism of action for aurodox (Response Mode)
Hoskisson, Paul (Principal Investigator)
01-Jan-2025 - 31-Jan-2027
Engineering Streptomyces bacteria for the sustainable manufacture of antibiotics
Hoskisson, Paul (Principal Investigator)
14-Jan-2024 - 13-Jan-2026
Taming of the Streptomycete: Understanding the rules of domestication in antibiotic-producing bacteria
Hoskisson, Paul (Principal Investigator)
01-Jan-2023 - 30-Jan-2026
Lost in Translation: reassessing bldA control of antibiotic biosynthesis
Hoskisson, Paul (Principal Investigator)
01-Jan-2023 - 30-Jan-2026
BIO-ART: Multiscale understanding of BIOfilms and microBIOmes in Acute Recurrent Tonsillitis (Fellowship for Catriona Douglas, NHS)
McConnell, Gail (Principal Investigator) Hoskisson, Paul (Co-investigator) Shu, Will (Co-investigator)
09-Jan-2023 - 08-Jan-2026

More projects

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Contact

Professor Paul Hoskisson
Strathclyde Institute of Pharmacy and Biomedical Sciences

Email: paul.hoskisson@strath.ac.uk
Tel: 548 2819